P450 Isoform | IC50 (µM) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Lumasiran | Cemdisiran | Vutrisiran | |||||||
−NADPH | +NADPH | Ratio | −NADPH | +NADPH | Ratio | −NADPH | +NADPH | Ratio | |
CYP1A2 | >612 | >612 | 1 | >596 | >596 | 1 | >612 | >612 | 1 |
CYP2B6 | >612 | >612 | 1 | >596 | >596 | 1 | >612 | >612 | 1 |
CYP2C8 | >612 | >612 | 1 | >596 | >596 | 1 | >612 | >612 | 1 |
CYP2C9 | >612 | >612 | 1 | >596 | >596 | 1 | >612 | >612 | 1 |
CYP2C19 | >612 | >612 | 1 | >596 | >596 | 1 | >612 | >612 | 1 |
CYP2D6 | >612 | >612 | 1 | >596 | >596 | 1 | >612 | >612 | 1 |
CYP3A4/5 (midazolam) | >612 | >612 | 1 | >596 | >596 | 1 | >612 | >612 | 1 |
CYP3A4/5 (testosterone) | >612 | >612 | 1 | >596 | >596 | 1 | >612 | >612 | 1 |