Validation of 50 kDa MWMCO ultrafiltration method for determination of fu,plasma and fu,liver using well characterized small molecules
SM | Matrix (Human) | fu (Measured) | fu (Reference) | Reference Method |
---|---|---|---|---|
Antipyrine | Plasma | 0.867 ± 0.110 | 0.9 | Ultracentrifugation |
Timolol | Plasma | 0.347 ± 0.074 | 0.4 | Ultracentrifugation |
Warfarin | Plasma | 0.043 ± 0.007 | 0.01a | Ultracentrifugation |
Rosuvastatin | Liver homogenate | 0.14 ± 0.03 | 0.23b | Equilibrium dialysis |