TABLE 1

Maximum over minimum point estimates within each study for mean clinical change with all CYP3A substrates compared with sensitive CYP3A substrates

InducerMax AUCR/Min AUCR
All SubstratesCYP3A Sensitive
Aprepitant7.53.3
Bosentan2.22.0
Efavirenz184.0
Lersivirine2.21.8
Nelfinavir125.5
Omeprazole8.23.4
Phenytoin205.5
Rifampicin277213
Ritonavir30749.1
Saquinavir7.96.8
Terbinafine5.82.8
  • AUCR, area under the curve ratio.

  • Adapted from Kenny et al. (2018), with permission.