TABLE 2

Effect of inducer and substrate on area under the curve ratio (AUCR)

InducerAUCR of Object at Inducer Steady State
midvcztrzsmvalfalpampartatzatvCafCsAdtgEEetrfeximainditzlopmet
efavirenz0.5910.2170.3960.3930.6260.4450.5860.430.6940.7740.7540.490.43
phenytoin0.280.4610.5290.510.070.70.479
omeprazole1.410.960.5541.131.001.410.9710.5330.8490.921
ritonavir26.40.1621.15.5712.02.483.2225.90.2450.6131.390.9675.5
rifampicin0.0160.050.090.0520.1170.1830.2400.1970.6290.3230.460.3450.1350.3460.2610.2370.3230.232
rufinamide0.6330.774
terbinafine0.7550.8110.841.300.861
bosentan0.6560.69
carbamazepine0.2550.58
saquinavir5.180.6841.170.931
nevirapine0.780.320.810.6780.6750.3770.512
  • alf, alfentanil; alp, alprazolam; amp, amprenavir; art, artemether; atv, atorvastatin; atz, atazanavir; caf, caffeine; CsA, cyclosporine A; dtg, dolutegravir; EE, ethinyl estradiol; etr, etravirine; fex, fexofenadine; ima, imatinib; ind, indinavir; itz, itraconazole; lop, lopinavir; met, methadone; mid, midazolam; smv, simvastatin; trz, triazolam; vcz, voriconazole; —, no data.