TABLE 1

Summary of biliary excretion index (BEI), apparent in vitro uptake clearance (CL_uptake,app) and biliary clearance (CL_biliary,app) values of digoxin, pravastatin, and TCA in various hepatic cell models

Substrates/Parameters	In Vitro Hepatic Models
Substrates/Parameters	HuH-7	Sandwich-Cultured Human Hepatocytes^{^a}	HepaRG^{^a}
Digoxin
BEI (%)	27–29	7–63^{^b}^–^{^d}
CL_uptake,app (μl/min per milligram protein)	1.0–1.3	0.69–2.8^{^b}^,^{^d}
CL_biliary,app (μl/min per milligram protein)	0.3–0.36	0.18–2.4^{^b}^–^{^d}
Pravastatin
BEI (%)	22	18–3^{^c}^,^{^e}
CL_uptake,app (μl/min per milligram protein)	0.4	1^{^e}
CL_biliary,app (μl/min per milligram protein)	0.086	0.25–0.55^{^c}^,^{^e}
TCA
BEI (%)	26–50	30–75^{^b}^,^{^d}^–^{^f}	27–39^{^g}^–^ⁱ
CL_uptake,app (μl/min per milligram protein)	1.2–2.1	2.7–20^{^b}^,^{^d}^–^{^f}	2.7–13.8^{^g}^,^{^h}
CL_biliary,app (μl/min per milligram protein)	0.5–0.7	0.8–25^{^b}^,^{^d}^–^{^f}	1–4^{^g}^,^{^h}

↵^a The values were adopted or calculated from the following references:
↵^b Bi et al. (2006).
↵^c Kimoto et al. (2017).
↵^d Swift et al. (2009).
↵^e Abe et al. (2009).
↵^f Ni et al. (2016).
↵^g Le Vee et al. (2013).
↵^h Susukida et al. (2016).
↵ⁱ Bachour-El Azzi et al. (2015).