TABLE 1

List of endogenous compounds of interest in the metabolomics analysis performed on WT and Oct1/2 dKO mice

IdentityPlatformProtonated MoleculeFold Change (Oct1/2 dKO/WT)
PlasmaUrine
PipecolateLC-MS Pos130.11.43***1.1
CadaverineGC-MS174N/D0.43*
3-methylglutarylcarnitineLC-MS Pos290.12.65**1.9
S-methylcysteineGC-MS162.11.040.54*
PutrescineGC-MS1740.930.62**
DocosahexaenoateLC-MS Neg327.31.35**N/D
DihomolinolenateLC-MS Neg305.41.26*N/D
ArachidonateLC-MS Neg303.41.28*N/D
DocosapentaenoateLC-MS Neg329.42.23**N/D
Mead acidLC-MS Neg305.41.51**N/D
12,13-DiHOMELC-MS Neg313.41.69**N/D
CholineLC-MS Pos104.21.21*N/D
1-DocosahexaenoylglycerophosphocholineLC-MS Pos568.41.14*N/D
1-Docosahexaenoyl-glycerophosphoethanolamineLC-MS Neg524.31.31*N/D
N1-methyladenosineLC-MS Pos282.12.78**0.84
3-UreidopropionateLC-MS Pos133.10.55*0.66*
Glycolate (hydroxyacetate)GC-MS1771.23*1.19
X-11478aLC-MS Neg165.22***N/D
X-11909aLC-MS Neg297.31.86**N/D
X-12257aLC-MS Neg269.13.13*0.77
X-16570aLC-MS Neg198.22.95*1.29
X-16575aLC-MS Neg293.12.04***N/D
X-16581aLC-MS Pos304.12.36***2.77**
X-17307aLC-MS Pos162.1N/D0.48**
X-18628aLC-MS Pos931.42.16*N/D
X-20568aLC-MS Pos188.1N/D0.56*
  • GC-MS, gas chromatography/mass spectrometry; LC-MS, liquid chromatography/mass spectrometry; Neg, negative; Pos, positive; 12, 13-DiHOME, (±)12,13-dihydroxy-9Z-octadecenoic acid. N/D, Not detected. *P < 0.05; **P < 0.01; ***P < 0.001, Welch's two-sample t test; value in Oct1/2 dKO mice vs. WT mice.