TABLE 1

List of endogenous compounds of interest in the metabolomics analysis performed on WT and Oct1/2 dKO mice

Identity	Platform	Protonated Molecule	Fold Change (Oct1/2 dKO/WT)
Identity	Platform	Protonated Molecule	Plasma	Urine
Pipecolate	LC-MS Pos	130.1	1.43***	1.1
Cadaverine	GC-MS	174	N/D	0.43*
3-methylglutarylcarnitine	LC-MS Pos	290.1	2.65**	1.9
S-methylcysteine	GC-MS	162.1	1.04	0.54*
Putrescine	GC-MS	174	0.93	0.62**
Docosahexaenoate	LC-MS Neg	327.3	1.35**	N/D
Dihomolinolenate	LC-MS Neg	305.4	1.26*	N/D
Arachidonate	LC-MS Neg	303.4	1.28*	N/D
Docosapentaenoate	LC-MS Neg	329.4	2.23**	N/D
Mead acid	LC-MS Neg	305.4	1.51**	N/D
12,13-DiHOME	LC-MS Neg	313.4	1.69**	N/D
Choline	LC-MS Pos	104.2	1.21*	N/D
1-Docosahexaenoylglycerophosphocholine	LC-MS Pos	568.4	1.14*	N/D
1-Docosahexaenoyl-glycerophosphoethanolamine	LC-MS Neg	524.3	1.31*	N/D
N¹-methyladenosine	LC-MS Pos	282.1	2.78**	0.84
3-Ureidopropionate	LC-MS Pos	133.1	0.55*	0.66*
Glycolate (hydroxyacetate)	GC-MS	177	1.23*	1.19
X-11478^a	LC-MS Neg	165.2	2***	N/D
X-11909^a	LC-MS Neg	297.3	1.86**	N/D
X-12257^a	LC-MS Neg	269.1	3.13*	0.77
X-16570^a	LC-MS Neg	198.2	2.95*	1.29
X-16575^a	LC-MS Neg	293.1	2.04***	N/D
X-16581^a	LC-MS Pos	304.1	2.36***	2.77**
X-17307^a	LC-MS Pos	162.1	N/D	0.48**
X-18628^a	LC-MS Pos	931.4	2.16*	N/D
X-20568^a	LC-MS Pos	188.1	N/D	0.56*

GC-MS, gas chromatography/mass spectrometry; LC-MS, liquid chromatography/mass spectrometry; Neg, negative; Pos, positive; 12, 13-DiHOME, (±)12,13-dihydroxy-9Z-octadecenoic acid. N/D, Not detected. ^*P < 0.05; **P < 0.01; ***P < 0.001, Welch's two-sample t test; value in Oct1/2 dKO mice vs. WT mice.