TABLE 5

The AUCs of metformin and m1A in control and DX-619-treated monkeys

Treatment123Mean ± S.E.
m1A (nM·h)
 Control364216219266 ± 49
 +DX-619468361464431 ± 35
 Fold change1.291.672.121.72 ± 0.24
Metformin (μM·h)
 Control43.511.138.331.0 ± 10.0
 +DX-61991.926.577.665.3 ± 19.9
 Fold change2.112.392.032.18 ± 0.11