Parameter | m1A | Creatinine | ||||
---|---|---|---|---|---|---|
Younger | Older | Unit | Younger | Older | Unit | |
AUC0–24 h | 1.22 ± 0.22 | 1.29 ± 0.14 | μmol per h/l | 1.05 ± 0.12 | 1.04 ± 0.16 | mmol per h/l |
Xurine, 0–24 h | 17.2 ± 1.4 | 13.0 ± 0.9*** | μmol | 8.06 ± 0.79 | 6.61 ± 1.17 | mmol |
CLr,p | 244 ± 58 | 169 ± 22** | ml/min | 129 ± 18 | 108 ± 21 | ml/min |
AUC0–24 h, area under the plasma concentration-time curve from 0 to 24 hours; Xurine, 0–24 h, amount excreted into the urine from 0 to 24 hours.
↵** P < 0.01; ***P < 0.001.