TABLE 6

Pharmacokinetic parameters of m1A in younger and older Japanese volunteers

Each value was determined from the data shown in Fig. 7. The equations to calculate the kinetic parameters are described in Materials and Methods. Each value represents the mean ± S.D. of eight and seven subjects; Student’s two-tailed unpaired t test; younger vs. older. Subject information is shown in Supplemental Table 4.

Parameterm1ACreatinine
YoungerOlderUnitYoungerOlderUnit
AUC0–24 h1.22 ± 0.221.29 ± 0.14μmol per h/l1.05 ± 0.121.04 ± 0.16mmol per h/l
Xurine, 0–24 h17.2 ± 1.413.0 ± 0.9***μmol8.06 ± 0.796.61 ± 1.17mmol
CLr,p244 ± 58169 ± 22**ml/min129 ± 18108 ± 21ml/min
  • AUC0–24 h, area under the plasma concentration-time curve from 0 to 24 hours; Xurine, 0–24 h, amount excreted into the urine from 0 to 24 hours.

  • ** P < 0.01; ***P < 0.001.