Parameter | Uptake Transport | ||
---|---|---|---|
In Vitro Data (Initial Estimates) | Nelder-Mead | Hybrid | |
CLint,T (µl/min per 106 cells)a | 33.91 | 41.33 (40.18, 42.47) | — |
CLPD (µl/min per 106 cells)b | 1.09 × 10−5 (Fixed) | ||
R2 | 0.97 | — | |
AIC | −16.92 | — | |
AICc | −16.44 | — |
AIC, Akaike information criterion; AICc, Akaike information criterion corrected.
↵a The CLint,T estimates were derived from the conventional two-step approach (Supplemental Fig. 2).
↵b Fixed using the CLPD value estimated from Ppass = 12.88 × 10−6 cm/s using eq. 3 since large S.E. values have been observed with CLPD values estimated using 2-minute incubations (Ménochet et al., 2012).