TABLE 1

Summary of fraction unbound (f_u) values of warfarin and pitavastatin in plasma, brain, and liver of F344 (wild type) and Nagase analbuminemic rats (NAR)

Compound	f_u,plasma		f_u,brain		f_u,liver
Compound	NAR	F344	NAR	F344	NAR	F344
Warfarin	0.43	0.0031	0.33	0.24	0.097	0.078
Pitavastatin	0.078	0.0079	0.022	0.022	0.018	0.023