Summary of total AUC0–8 hours, free AUC0–8 hours, and Kp,u,u of warfarin and pitavastatin in plasma, brain, and liver in F344 (wild type) and NAR animals (N = 3)
The AUC0–8 hours was a composite constructed from three independent measurements. Units for brain and liver AUC0–8 hours is nmol/g*h; units for plasma AUC0–8 hours is µM*h.
| F344 | NAR | |||||
|---|---|---|---|---|---|---|
| Total AUC0–8 hours | Free AUC0–8 hours | Kp,u,u | Total AUC0–8 hours | Free AUC0–8 hours | Kp,u,u | |
| Warfarin | ||||||
| Brain | 3.1 | 0.73 | 0.89 | 1.7 | 0.57 | 0.43 |
| Liver | 89 | 6.9 | 8.4 | 60 | 5.9 | 4.4 |
| Plasma | 260 | 0.82 | — | 3.1 | 1.3 | — |
| Pitavastatin | ||||||
| Brain | BLQ | BLQ | NA | BLQ | BLQ | NA |
| Liver | 40 | 0.93 | 110 | 20 | 0.36 | 18 |
| Plasma | 1.1 | 0.0088 | — | 0.26 | 0.020 | — |
AUC, area under the curve; BLQ, below the limit of quantitation; Kp,u,u, free tissue-to-free plasma partition ratio; NA, not applicable; NAR, Nagase analbuminemic rats.