TABLE 4

Comparison of CYP and accessory protein (P450 oxidoreductase, POR; cytochrome b5A, CYB5A) abundance measured in liver microsomes from 32 male and 27 female dogs

Shown are the median and interquartile range (25%–75%) for each sex and the results (P value) of Mann–Whitney U test comparing sexes.

Liver Microsome Abundance
Median (25%–75%) pmol/mg Protein
ProteinMales (N = 32)Females (N = 27)P Value
CYP1A10.1 (0.0–2.4)0.9 (0.0–3.2)0.11
CYP1A264 (39–84)61 (43–90)0.86
CYP2A138.3 (4.8–13.6)11 (7–17)0.036
CYP2A258.1 (6.5–10.8)5.8 (4.9–9.0)0.029
CYP2B1173 (44–101)79 (48–116)0.37
CYP2C2151 (47–65)46 (36–57)0.042
CYP2C41a4.3 (2.0–8.3)7.8 (7.5–10.0)0.21
CYP2D15136 (116–172)140 (117–167)0.92
CYP2E172 (61–88)72 (61–79)0.55
CYP3A12115 (91–142)133 (100–152)0.23
CYP3A263.1 (2.2–4.7)4.0 (3.0–5.2)0.10
POR39 (30–45)40 (35–47)0.16
CYB5A436 (382–499)429 (401–461)0.59
  • a Note that the results given for CYP2C41 are for the 12 dogs that express at least one copy of the CYP2C41 gene (four males and eight females).