TABLE 2

Correlation of the abundance of CYPs and accessory proteins (P450 oxidoreductase, POR; cytochrome b5A, CYB5A) measured by quantitative mass spectrometry with the abundance of CYP1A2 and CYP2B11 measured by semiquantitative immunoblot in the same set of dog liver microsomes (N = 20)

Shown are the Spearman correlation coefficients (Rs) and the associated P values for each correlation.

Spearman Correlation Coefficient (P Value)
Immunoblot CYP1A2Immunoblot CYP2B11
CYP1A10.25 (0.29)−0.08 (0.72)
CYP1A20.69 (0.0007)0.26 (0.27)
CYP2A13−0.24 (0.31)−0.28 (0.22)
CYP2A250.23 (0.33)0.09 (0.71)
CYP2B110.33 (0.15)0.89 (<0.0001)
CYP2C21−0.04 (0.87)0.2 (0.4)
CYP2D15−0.24 (0.31)−0.28 (0.23)
CYP2E1−0.28 (0.23)−0.64 (0.003)
CYP3A120.32 (0.17)0.23 (0.32)
CYP3A26−0.06 (0.79)0.27 (0.26)
POR0.44 (0.05)0.13 (0.57)
CYB5A0.12 (0.4)0.22 (0.34)