Inhibition of uptake of fenoterol in human hepatocytes by CsA (2 and 10 µM) and pyrimethamine (100 µM)
The hepatic uptake clearance was determined using the data in Fig. 3.
Parameter | Control | With 2 µM CsA | With 10 µM CsA | With 100 µM Pyrimethamine | 4°C |
---|---|---|---|---|---|
Uptake clearance (µl/min per 106 cells) | 12.2 | 6.4 | 5.7 | 2.5 | 1.2 |
Uptake clearance Inhibition (%) | NA | 48 | 54 | 80 | 90 |