Inhibition of uptake of fenoterol in human hepatocytes by CsA (2 and 10 µM) and pyrimethamine (100 µM)
The hepatic uptake clearance was determined using the data in Fig. 3.
| Parameter | Control | With 2 µM CsA | With 10 µM CsA | With 100 µM Pyrimethamine | 4°C |
|---|---|---|---|---|---|
| Uptake clearance (µl/min per 106 cells) | 12.2 | 6.4 | 5.7 | 2.5 | 1.2 |
| Uptake clearance Inhibition (%) | NA | 48 | 54 | 80 | 90 |