Quantification of the major radioactive components in urine, feces and bile extracts following intravenous or oral administration of [14C]nemiralisib
| Mean % Matrix Radioactivity (Mean % Dose) | ||||
|---|---|---|---|---|
| Urine Oral 6-Subject pool | Feces | Bile Intravenous 6-Subject pool | ||
| Intravenous | Oral | |||
| ID | 6-Subject pool | 6-Subject pool | ||
| P (nemiralisib) | 43.3 (2.2) | 13.2 (6.8) | 41.0 (21.6) | 52.4 |
| M3 | 11.9 (0.6) | ND | ND | ND |
| M1(GSK2330979) and/or M9 | 14.7 (0.8) | 8.3 (4.3) | 14.7 (7.8)a 1.8 (1.0)b | 12.1 |
| M6 and/or M7 | ND | 8.8 (4.6) | 4.4 (2.3) | 6.3 |
| M14 and/or M15 | 7.6 (0.4) | 12.8 (6.6) | 2.0 (1.1) | 7.4 |
| Total radioactive material assignedc | 77.4 (4.0) | 43.1 (22.3) | 63.9 (33.7) | 78.1 |
| % Administered dose in matrix poold | 5.2 | 51.7 | 72.1 | N/A |
| Total % dose excreted in matrixe | 5.66 | 51.7 | 79.5 | N/A |
↵a M1 (GSK2330979).
↵b M9.
↵c Total radioactive material assigned is the sum of the % matrix radioactivity (and % dose) for all identified metabolites in the analyzed pool.
↵d % Administered dose in the matrix pool represents approximately ≥90% of the radioactivity excreted via that route and is quoted for all matrices other than bile. Bile string collection is not quantitative.
↵e Total % dose excreted in matrix is the mean figure from the ADME study.