TABLE 2

Physicochemical properties, permeability, and lysosomal trapping of OCT1 substrates

Imipramine was used as a positive control for lysosomal trapping.

LogD 7.4Basic pKaMDCK Permeability (cm/s × 10−6)Ratio Control:NH4Cl
Sumatriptan−1.249.51.00.36
Fenoterol0.339.61.91.4
Ondansetron2.117.3584.5
Tropisetron0.709.3342.5
Imipramine2.489.2362.5