TABLE 1

N-Oxygenation of oxymorphone, oxycodone, and naltrexone by highly purified human and mouse FMOs

The number of incubations was n = 3 or 4.

EnzymeOxymorphoneOxycodoneNaltrexone
(nmol N-oxide formed/min)/mg protein
mFMO127.9a18.320.9
hFMO330.926.8ND
mFMO311.911.89.4
mFMO51.30.7ND
hFMO50.90.60.6

  • mFMO, mouse FMO; hFMO, human FMO; ND, not detectable.

  • ↵a Specific activity for NADPH consumption.