Retro-reduction of oxycodone N-oxide by human liver microsomes (pH 7.4)
Values are expressed as means ± S.D., mean of four determinations, pH 7.4, 10-min incubation.
Human Liver Microsomes | Oxycodone | Oxycodone N-Oxide | Noroxycodone | Oxymorphone | Noroxymorphone |
---|---|---|---|---|---|
(nmol/ml)/mg protein | nmol/ml | (nmol/ml)/mg protein | |||
HK37a | 48.6 ± 3.1 | 115.9 ± 5.8 | 7.5 ± 0.5 | 0.2 ± 0.01 | ND |
HH18b | 5.0 ± 0.2 | 9.4 ± 0.5 | 0.6 ± 0.02 | ND | ND |