Effect of highly purified human FMO3 on oxycodone N-oxide metabolism
Values are expressed as means ± S.D., mean of four determinations, pH 7.4. Oxycodone N-oxide was present at 20 µM.
| Time (min) | Oxycodone | Oxycodone N-Oxide | Noroxycodone | Oxymorphone | Noroxymorphone |
|---|---|---|---|---|---|
| min | (nmol/ml)/mg protein | nmol/mg | (nmol/ml)/mg protein | ||
| 20 | 0.001 ± 0.0002 | 2.4 ± 0.05 | 0.002 ± 0.0004 | ND | ND |
ND, not detected.