TABLE 13

Effect of quinone reductase inhibitors and hemoglobin on human liver S-9 metabolism of oxycodone N-oxide

Values are expressed as means ± S.D., mean of four determinations, pH 7.4. Oxycodone N-oxide was present at 20 µM. Incubations were conducted for 30 min.

DescriptionOxycodoneOxycodone N-OxideNoroxycodoneOxymorphoneNoroxymorphone
(nmol/min)/mg protein
Complete0.09 ± 0.0060.01 ± 0.0010.02 ± 0.0010.001 ± 0.0ND
+KCN0.01 ± 0.0010.004 ± 0.0010.001 ± 0.0NDND
+Na arsenite +Menadione0.01 ± 0.0010.004 ± 0.0010.001 ± 0.0NDND
+Hemoglobin
+Menadione
0.1 ± 0.0020.002 ± 0.0020.005 ± 0.0010.0004 ± 0.0ND
  • ND, not detected.