TABLE 1

List of CES1 substrates

ACE (Angiotensin-Converting Enzyme) InhibitorCNS (Central Nervous System) agentsAntihyperlidpidemia agents
EnalaprilaMethylphenidateClofibrate
ImidaprilaCocaineFenofibrate
BenzaprilaHeroin
QuinaprilaMepridineAdrenal glucocorticoid
RamiprilaFlumazenilCiclesonidea
TrandolaprilaRufinamide
Antiviral agentsAnticancer agentsChemical warfare agents
OseltamiviraCapecitabineaSarin
SofosbuviraIrinotecanaSoman
Tenofovir alafenamideaTelotristat etiprateaTabun
Endogenous CompoundsAntiplatelets/anticoagulantsPesticides
CholesterolClopidogrelTrans-permethrin
Fatty acid ethyl estersDabigatranaPara-nitrophenyl valerate
Angiotensin receptor-neprilysin inhibitor (ARNi)Immunosuppressive agentsOthers
SacubitrilaMycophenolate mofetilaDimethyl fumaratea
Oxybutynin
  • a Prodrugs that need CES1 activation.