TABLE 2

In vitro inhibition and induction parameters used for the simulation

	Reversible Inhibition	Time-Dependent Inhibition		Induction
Precipitant	K_i (μM)	K_I (μM)	k_inact (/min)	EC₅₀ (μM)	E_max
Atomoxetine	41.6	—		—
Atorvastatin	51.8	29.9	0.019	16.6^{^a}	13.5^{^a}
Azithromycin	—	599	0.013	—
Casopitant	4.26	0.474	0.011	2.04	9.22
Cimetidine	202	76.8	0.0060	—
Deferasirox	106	58.6	0.0044	—
Ethinyl estradiol	78.1	12.3	0.053	20.0^{^b}	69.0^{^b}
Everolimus	0.647	0.675	0.016	0.00657	2.42
Felodipine	0.982	4.49	0.015	1.07	6.66
Fluoxetine	13.5	3.90	0.0015	0.50^{^b}	2.1^{^b}
Fluvoxamine	23.5	1.85	0.00087	28.0	4.42
Pazopanib	9.31	4.00	0.017	0.807	2.43
Ranitidine	847	491	0.0036	—
Roxithromycin	43.9	0.926	0.0014	—
Simvastatin	0.462	19.4	0.0071	5.75	43.6
Suvorexant	1.11	0.797	0.039	14.0^{^c}	11.0^{^c}
Tadalafil	32.7	4.74	0.043	1.82	21.0

—, no inhibition or induction was observed.
↵^a Vieira et al. (2014).
↵^b Fahmi et al. (2008).
↵^c Prueksaritanont et al. (2013).