Prospective drug interaction predictions with P4503A4 inhibitors clarithromycin and erythromycin
| Simulated Ratio with Clarithromycin | Simulated Ratio with Erythromycin | |
|---|---|---|
| Simulated individuals | 1000 | 1000 |
| Reference for study design | Gorski et al. 1998 | Olkkola et al. 1994 |
| Simulated study design | 500 mg twice a day for 7 days and 4 mg midazolam on day 7 (2 h after the first dose of clarithromycin) | 500 mg erythromycin three times a day for 1 wk and 15 mg midazolam on day 6 (2 h after second dose of the day) |
| Age range for simulated individualsa | 21–62 | 21–62 |
| Simulated gender ratioa | Males | Males |
| AUC0-inf geometric mean ratio (5th and 95th centile) | 1.71 (1.27–2.48) | 1.67 (1.22–2.40) |
AUC0-inf, area under the plasma concentration-time curve time zero (pre-dose) extrapolated to infinite time.
↵a Demographics based on NCT03398421.