Effect of paclitaxel on AUC–3–7h of endogenous OATP1B substrates AUC–3–7h of the endogenous OATP1B substrates were calculated. AUC–3–7r are presented as mean ± S.E.M. Fold changes are presented as GMR and 90% CI (n = 10). GMR, geometric mean ratio.
| Compounds | Control | + Paclitaxel | Fold Change | |
|---|---|---|---|---|
| CPI | (nM × h) | 22.1 ± 1.7 | 61.4 ± 4.3 | 2.8 (2.5, 3.1) |
| CPIII | (nM × h) | 4.48 ± 0.34 | 14.1 ± 1.3 | 3.1 (2.6, 3.7) |
| GCDCA-S | (μM × h) | 2.06 ± 0.45 | 5.71 ± 1.0 | 2.9 (2.2, 3.9) |
| GDCA-S | (μM × h) | 0.501 ± 0.09 | 2.2 ± 0.45 | 4.0 (2.8, 5.8) |
| LCA-S | (μM × h) | 0.694 ± 0.16 | 1.46 ± 0.38 | 2.0 (1.2, 3.5) |
| GLCA-S | (μM × h) | 4.15 ± 1.4 | 10.4 ± 3.3 | 2.2 (1.4, 3.6) |
| TLCA-S | (μM × h) | 0.857 ± 0.22 | 1.94 ± 0.57 | 2.0 (1.3, 3.0) |
| GCDCA-G | (nM × h) | 20.6 ± 4.1 | 52.2 ± 10 | 2.5 (1.8, 3.4) |
| GDCA-G | (nM × h) | 94.4 ± 29 | 211 ± 46 | 2.5 (1.8, 3.4) |
| CDCA-24G | (nM × h) | 141 ± 33 | 369 ± 79 | 3.0 (2.2, 4.0) |