Oral | Intravenous | Bioavailability | ||||
---|---|---|---|---|---|---|
Genotype | Wild-type | Oatp2b1−/− | Wild-type | Oatp2b1−/− | Wild-type | Oatp2b1−/− |
Females | ||||||
Cmax (µg/ml) | 3.90 ± 1.20 | 1.31 ± 0.33* | 36.2 ± 4.42 | 28.2 ± 4.84 | 31.5% | 12.8% |
AUClast (µg × h/ml) | 7.80 ± 2.15 | 2.53 ± 0.57* | 24.8 ± 3.44 | 19.8 ± 2.25 | ||
Males | ||||||
Cmax (µg/ml) | 4.96 ± 1.58 | 1.92 ± 0.62* | 25.5 ± 1.53 | 17.7 ± 1.40* | 29.6% | 20.5% |
AUClast (µg × h/ml) | 5.84 ± 1.56 | 2.59 ± 0.45* | 19.8 ± 1.53 | 12.6 ± 0.58* |
↵* P < 0.05 vs. wild-type (two-sided student t-test).