TABLE 4

Forty-one drugs metabolized by sexually dimorphic P450s

Drug	Drug class	DMET 1		DMET 2
Drug	Drug class	DMET	FD	DMET	FD
Amlodipine^{^a}	Ca channel blocker	Cyp3a2	∼2500 M > F
Astemizole^{^a}^, ^{^b}	Antihistamine	Cyp3a2	∼2500 M > F
Azelastine^{^a}^, ^{^b}	Antihistamine	Cyp2c11	∼2200 M > F	Cyp3a2	∼2500 M > F
Beclomethasone^{^a}^, ^{^b}	Corticosteroid	Cyp3a2	∼2500 M > F
Buspirone^{^a}	Anxiolytic	Cyp3a2	∼2500 M > F
Cetirizine^{^a}	Antihistamine	Cyp3a2	∼2500 M > F
Clonazepam	Antiepileptics	Cyp3a62	∼6 M > F
Dextromethorphan^{^a}^, ^{^b}	Cough suppressant	Cyp3a62	∼6 M > F
Digoxin^{^a}	Cardiac glycoside	Cyp3a2	∼2500 M > F
Doxorubicin^{^a}^, ^{^b}	Antineoplastic	Cyp3a2	∼2500 M > F
Ebastine^{^a}	Antihistamine	Cyp3a2	∼2500 M > F
Ethinyl estradiol^{^a}^, ^{^b}	Hormone	Cyp3a62	∼6 M > F	Cyp3a2	∼2500 M > F
Etonogestrel	Hormone	Cyp3a2	∼2500 M > F
Fentanyl^{^a}	Analgesics opioid	Cyp3a62	∼6 M > F	Cyp3a2	∼2500 M > F
Fexofenadine^{^a}^, ^{^b}	Antihistamine	Cyp3a62	∼6 M > F	Cyp3a2	∼2500 M > F
Flunisolide^{^a}	Corticosteroid	Cyp3a2	∼2500 M > F
Fosphenytoin	Antiepileptic	Cyp2c11	∼2200 M > F
Glimepiride^{^a}^, ^{^b}	Antihyperglycemic	Cyp2c11	∼2200 M > F
Hydrocodone	Analgesics opioid	Cyp3a2	∼2500 M > F
Ibutilide^{^a}^, ^{^b}	Antiarrhythmic	Cyp3a2	∼2500 M > F
Irinotecan^{^a}^, ^{^b}	Antineoplastic	Cyp3a2	∼2500 M > F
Ketoprofen	NSAID	Cyp2c11	∼2200 M > F
Levobupivacaine^{^a}	Anesthetic, local	Cyp3a2	∼2500 M > F
Lidocaine^{^a}	Anesthetic, local	Cyp3a2	∼2500 M > F
Loratadine^{^a}	Antihistamine	Cyp3a2	∼2500 M > F
Medroxyprogesterone^{^a}	Hormone	Cyp3a2	∼2500 M > F
Mometasone^{^a}	Corticosteroid	Cyp3a2	∼2500 M > F	Cyp3a62	∼6 M > F
Naproxen	NSAID	Cyp2c11	∼2200 M > F
Nifedipine^{^a}^, ^{^b}	Ca channel blocker	Cyp3a2	∼2500 M > F
Nimodipine^{^a}^, ^{^b}	Ca channel blocker	Cyp3a2	∼2500 M > F
Norethindrone^{^a}	Hormone	Cyp3a2	∼2500 M > F
Oxybutynin^{^a}	Anticholinergic	Cyp3a2	∼2500 M > F
Phentermine	Antiobesity	Cyp3a2	∼2500 M > F
Phenytoin^{^a}^, ^{^b}	Antiepileptic	Cyp2c11	∼2200 M > F
Pravastatin^{^a}^, ^{^b}	Lipid modifying	Cyp3a2	∼2500 M > F
Sertindole^{^a}^, ^{^b}	Antipsychotic	Cyp3a62	∼6 M > F
Tamsulosin^{^a}^, ^{^b}	Antiadrinergic	Cyp3a2	∼2500 M > F
Tazarotene^{^a}^, ^{^b}	Antipsoriatic	Cyp2c7	∼3 F > M
Terfenadine^{^a}^, ^{^b}	Antihistamine	Cyp3a2	∼2500 M > F
Trazodone^{^a}^, ^{^b}	Antidepressant	Cyp3a2	∼2500 M > F
Triazolam	Antianxiety	Cyp3a62	∼6 M > F

FD, fold difference in gene expression level; F > M, expression is higher in females than in males; M > F, expression is higher in males than in females; NSAID, nonsteroidal anti-inflammatory drug.
↵^a Thirty-three drugs tested for cytotoxicity in hepatocytes from one male and one female F344 rat.
↵^b Nineteen drugs selected for cytotoxicity testing in hepatocytes from a total of three male and three female F344 rats.