TABLE 3

Classes of HDAC inhibitors and their targets

Class	Examples	HDAC Targets	Potency Range^{^a}
Hydroxamates	SAHA, Trichostatin A (TSA), Belinostat, Panobinostat	Class I and IIb	nM–μM
Short chain fatty acids	Valproic Acid (VPA), Sodium Butyrate, Phenylbutyrate	Class I and IIa	mM
Cyclic peptides	Romidepsin, Apicidin	Class I	nM
Benzamides	MS-275, Mocetinostat, CI-994	Class I	μM

↵^a This potency range represents general IC₅₀ values (50% inhibitory concentrations) for purified HDACs as determined by HDAC activity assays.