TABLE 2

Absolute protein quantification mean values (picomoles per milligram protein; S.D. in parentheses) of non–cytochrome P450 enzymes in different segments of human intestinea A–J indicate 10 different intestinal segments from duodenum to ileum.

ProteinDuodenumJejunumIleumABCDEFGHIJLLOQb
CES19.14.12.814.97.26.64.24.44.73.43.53.33.51.9
(4.7)(2.9)(0.7)(11.5)(5.8)(n/a)(2.4)(3)(2.8)(1.7)(1.9)(1.6)(2.1)
CES269364668271875675662660466463175378475354.9
(168)(139)(215)(271)(366)(n/a)(157)(85)(141)(225)(348)(177)(265)
UGT1A11.81.81.32.12.32.22.01.81.92.02.11.91.70.32
(1)(0.6)(0.8)(0.8)(0.8)(n/a)(0.5)(0.7)(1.2)(1.3)(1)(0.8)(0.9)
UGT1A30.090.120.10.10.110.150.10.110.150.140.160.170.150.03
(0.06)(0.06)(0.1)(0.02)(0.02)(n/a)(0.03)(0.04)(0.11)(0.13)(0.11)(0.04)(0.06)
UGT1A1023.326.929.730.527.535.328.125.620.226.124.724.926.810.2
(6.3)(6.5)(10.8)(12)(7.2)(2.3)(8.6)(2.3)(2.2)(15.3)(8)(3.9)(10.4)
UGT2B72.73.02.92.63.43.83.63.34.34.75.25.64.60.17
(1.2)(0.9)(1.8)(0.6)(0.9)(n/a)(0.8)(1.2)(2.4)(2.8)(2.3)(0.9)(1.4)
UGT2B176.94.97.87.35.55.15.44.97.37.37.88.38.10.17
(3.5)(1.7)(3)(7.1)(5.8)(n/a)(4.7)(4.5)(6.8)(7.2)(7.4)(7.2)(7.1)
SULT1A19.59.96.97.515.36.84.611.312.57.45.128.4130.73
(7.4)(7.1)(5.1)(7.8)(12.5)(n/a)(2.8)(n/a)(10.5)(n/a)(n/a)(n/a)(16.3)
SULT2A17.913.55.69.522.77.38.723.121.913.828.236.916.20.3
(3.7)(7.4)(3.4)(7.2)(12.1)(n/a)(5.5)(n/a)(14.8)(n/a)(n/a)(n/a)(15.1)
  • LLOQ, lower limit of quantification.

  • a CES and UGT values are from membrane proteins, and SULTs are from cytosolic proteins.

  • b Picomoles per milligram protein.