TABLE 9

Interstrain comparison for hepatocyte CLint across three mouse strains and eight compounds

Hepatocyte CLint (µl/min per million cells)
BALB/cC57BL/6CD-1P value%CVBALB/c ÷ CD1C57BL/6 ÷ CD1
Amiodarone15 ± 0.4429 ± 7.526 ± 0.430.10320.591.1
Captopril<2.5 ± ND<2.5 ± ND<2.5 ± NDNDND1.01.0
Chlorpromazine16 ± 5.27.0 ± 0.055<2.5 ± ND0.070796.22.8
Dexamethasone6.7 ± 0.356.2 ± 1.24.8 ± 2.40.52171.41.3
Fluvastatin87 ± 1.148 ± 2.668 ± 0.310.00041*281.30.71
Levofloxacin4.1 ± 0.645.0 ± 0.446.5 ± 2.00.30230.640.77
Naproxen19 ± 3.38.5 ± 2.813 ± 1.60.058401.50.66
Propranolol310 ± 23250 ± 86160 ± 5.80.24311.91.6
  • ND, not determined.

  • * P value of 0.05 or less found by a one-way ANOVA test.