Measured t1/2 parameters and the interstrain comparisons for eight compounds
| Compound | Average t1/2 (h) | P value | %CV | BALB/c ÷ CD-1 | C57BL/6 ÷ CD-1 | ||
|---|---|---|---|---|---|---|---|
| BALB/c | C57BL/6 | CD-1 | |||||
| Amiodarone | 12 ± 2.1 | 11 ± 0.30 | 9.9 ± 1.3 | 0.46 | 8.5 | 1.2 | 1.1 |
| Captopril | 5.2 ± 1.9 | 6.5 ± 2.6 | 4.9 ± 2.4 | 0.68 | 15 | 1.0 | 1.3 |
| Chlorpromazine | 3.1 ± 1.1 | 9.1 ± 3.4 | 2.8 ± 1.1 | 0.020* | 71 | 1.1 | 3.2 |
| Dexamethasone | 2.5 ± 0.39 | 2.3 ± 1.1 | 4.0 ± 3.3 | 0.56 | 32 | 0.62 | 0.57 |
| Fluvastatin | 2.8 ± 0.67 | 4.5 ± 0.40 | 2.2 ± 0.70 | 0.039* | 38 | 1.3 | 2.1 |
| Levofloxacin | 2.7 ± 1.7 | 2.6 ± 1.9 | 2.5 ± 1.7 | 1.0 | 2.5 | 1.1 | 1.0 |
| Naproxen | 2.8 ± 0.21 | 5.7 ± 1.1 | 2.6 ± 0.44 | 0.0030* | 47 | 1.1 | 2.2 |
| Propranolol | 1.9 ± 0.47 | 4.4 ± 2.2 | 1.4 ± 0.85 | 0.079 | 63 | 1.3 | 3.2 |
↵* P value of 0.05 or less found by a one-way ANOVA test.