TABLE 6

Measured Cmax parameters and the interstrain comparisons for eight compounds

CompoundAverage Cmax (µM)P value%CVBALB/c ÷ CD-1C57BL/6 ÷ CD-1
BALB/cC57BL/6CD-1
Amiodarone0.32 ± 0.0780.33 ± 0.0330.24 ± 0.110.38171.31.4
Captopril9.6 ± 2.27.6 ± 4.76.1 ± 1.20.42231.61.2
Chlorpromazine0.19 ± 0.0660.082 ± 0.00720.17 ± 0.0560.095391.10.48
Dexamethasone3.1 ± 0.795.0 ± 0.841.7 ± 0.280.0028*511.82.9
Fluvastatin1.0 ± 0.162.6 ± 0.511.2 ± 0.160.0020*540.832.2
Levofloxacin0.49 ± 0.110.49 ± 0.0510.67 ± 0.30.46190.730.73
Naproxen88 ± 7.697 ± 1590 ± 130.685.21.01.1
Propranolol0.024 ± 0.00430.18 ± 0.00930.13 ± 0.0840.021*720.181.4
  • * P value of 0.05 or less found by a one-way ANOVA test.