TABLE 2

Measured CL parameters and the interstrain comparisons for eight compounds

CompoundAverage CL ± S.D. (l/h per kilogram)P value%CVBALB/c ÷ CD-1C57BL/6 ÷ CD-1
BALB/cC57BL/6CD-1
Amiodarone1.2 ± 0.0400.73 ± 0.0611.4 ± 0.200.0017*300.870.53
Captopril0.32 ± 0.0870.21 ± 0.0880.44 ± 0.0800.049*350.730.48
Chlorpromazine7.4 ± 1.21.7 ± 0.464.5 ± 0.460.00039*631.70.38
Dexamethasone1.0 ± 0.241.1 ± 0.461.3 ± 0.380.65120.780.87
Fluvastatin2.7 ± 0.00711.6 ± 0.0712.2 ± 0.340.027*251.20.75
Levofloxacin3.9 ± 0.293.7 ± 0.344.4 ± 1.10.469.40.880.84
Naproxen0.073 ± 0.00850.061 ± 0.00940.065 ± 0.00500.268.91.10.93
Propranolol4.0 ± 1.23.1 ± 0.864.5 ± 0.460.45180.880.69
  • * P value of 0.05 or less found by a one-way ANOVA test.