TABLE 3

Measured Vss parameters and the interstrain comparisons for eight compounds

CompoundAverage Vss ± S.D. (l/kg)P value%CVBALB/c ÷ CD-1C57BL/6 ÷ CD-1
BALB/cC57BL/6CD-1
Amiodarone18 ± 2.810 ± 0.4515 ± 4.40.036*291.20.67
Captopril1.6 ± 0.0201.6 ± 0.682.2 ± 0.780.42200.720.72
Chlorpromazine27 ± 4.718 ± 3.015 ± 4.90.031*321.81.2
Dexamethasone2.8 ± 0.424.1 ± 3.74.6 ± 2.10.69240.620.89
Fluvastatin4.1 ± 1.15.0 ± 1.44.1 ± 1.30.71121.01.2
Levofloxacin8.3 ± 3.87.4 ± 1.98.5 ± 2.00.877.40.970.87
Naproxen0.22 ± 0.0240.26 ± 0.0280.22 ± 0.0240.14100.971.2
Propranolol9.4 ± 2.411 ± 2.46.2 ± 5.10.12271.51.7
  • * P value of 0.05 or less found by a one-way ANOVA test.