TABLE 8

Chlorpromazine PK parameters for studies performed on three separate days

Study 1Study 2Study 3P value%CV
CD-1CL (l/h per kilogram)4.5 ± 0.465.5 ± 0.564.4 ± 0.720.1113
Vss (l/kg)15 ± 4.913 ± 2.312 ± 6.20.7810
t1/2 (h)2.8 ± 1.12.3 ± 0.482.7 ± 1.50.8510
Cmax (µM)0.17 ± 0.0560.12 ± 0.0150.20 ± 0.0150.07525
Tmax (h)0.5 (0.5–1)1 (0.5–2)1 (0.5–1)NDND
F (%)17 ± 1.118 ± 3.221 ± 5.90.4011
C57BL/6CL (l/h per kilogram)1.7 ± 0.461.6 ± ND2.6 ± 1.10.4429
Vss (l/kg)18 ± 3.021 ± ND19 ± 4.90.769.1
t1/2 (h)9.1 ± 3.412 ± ND7.1 ± 4.30.5627
Cmax (µM)0.082 ± 0.00720.075 ± 0.0120.11 ± 0.0250.07021
Tmax (h)1 (1–1)0.5 (0.5–1)0.5 (0.5–1)NDND
F (%)7.1 ± 1.110 ± 3.910 ± 2.20.3819
  • ND, not determined.