TABLE 2

Pharmacokinetic parameters for propofol and its metabolite propofol glucuronide

Propofol (100 mg/kg, i.p.) was administered to wild-type and Rev-erbα^−/− mice at ZT6 or ZT18.

Parameter	Unit	ZT6		ZT18
Parameter	Unit	Wild type	Rev-erbα^−/−	Wild type	Rev-erbα^−/−
Propofol
AUC_{0–2 h}	μg/ml^*h	2.38 ± 0.25	2.80 ± 0.23	2.65 ± 0.28	2.74 ± 0.29
MRT	h	1.44 ± 0.13	1.53 ± 0.12	1.04 ± 0.04	1.43 ± 0.37
V_ss	l/kg	21.9 ± 0.88	24.6 ± 1.57	17.0 ± 1.18	26.4 ± 3.11
CL	l/h per kilogram	16.4 ± 0.70	12.8 ± 0.04	16.0 ± 0.87	15.0 ± 2.12
Propofol glucuronide
AUC_{0–2 h}	μg/ml^*h	5.13 ± 0.31	2.86 ± 0.29^*	3.85 ± 0.18^#	2.90 ± 0.15^*
Metabolism ratio^{^a}		2.35	1.02	1.53	1.17