TABLE 2

Percent of sample radioactivity as [¹⁴C]LY3202626 or metabolites of [¹⁴C]LY3202626 in pooled human plasma samples after a single oral dose of 10 mg of [¹⁴C]LY3202626

Peak	Protonated Molecular ion [M + H]⁺	Proposed Metabolite Identification	Percent of Radioactivity (% of Run)
Peak	Protonated Molecular ion [M + H]⁺	Proposed Metabolite Identification	4 hour	144 hour	288 hour	AUC Pool (0–24 hours)
Parent	499	LY3202626	43.4	8.96	1.63	38
M1	363	Amide hydrolysis to the amine (aniline) (LSN3200635)	1.28	17.2	24.3	2.27
M2	485	O-desmethyl (LSN3207841)	4.13	11.3	10.3	4.41
M3	155	Amide hydrolysis to the carboxylic acid (LSN3170994)	3.64	<1.0	<1.0	3.86
M4	212	M3 + glycine (LSN3329581)	10.3	1.57	<1.0	11.9
M5	405	N-acetyl of M1 (LSN3226305)	<0.5	<1.0	<1.0	<1.0
M16	460	M2 − O (reduction) (LSN3420637)	<1.0	2.1	1.81	<1.0
Region A			30.0	46.9	54.3	33.5
Total			92.76	88.03	92.34	93.94
Total radioactivity recovery			103.0	101.3	103.0	96.7