Percent dose of LY3202626 and its metabolites excreted in urine and feces from healthy human subjects after a single oral dose of 10 mg of [14C]LY3202626 from 0 to 508 hours
| Peak | Protonated Molecular ion [M + H]+ | Proposed Metabolite Identification | Percent of Dose | ||
|---|---|---|---|---|---|
| Urine | Feces | Total | |||
| Parent | 499 | LY3202626 | 2.25 | 2.02 | 4.27 |
| M1 | 363 | Amide hydrolysis to the amine (aniline) (LSN3200635) | 1.21 | ND | 1.21 |
| M2 | 485 | O-desmethyl (LSN3207841) | 8.88 | 10.75 | 19.63 |
| M4 | 212 | M3 + glycine (LSN3329581) | 21.27 | ND | 21.27 |
| M5 | 405 | N-acetyl of M1 (LSN3226305) | 0.18 | 1.32 | 1.5 |
| M16 | 460 | M2 − O (reduction) (LSN3420637) | ND | 6.94 | 6.94 |
| M21 | 499 | Same mass as parent | 1.34 | 1.55 | 2.89 |
| Total % identified | 35.15 | 22.57 | 57.72 | ||
| Total % dose in the sample analyzed | 40.99 | 28.81 | 69.8 | ||