TABLE 6

Mean systemic exposures of CP in cynomolgus monkeys after a single intravenous dose of 2 mg/kg FSM alone, PROB alone (i.v., 40 mg/kg), and PROB with FSM

Data are presented as means ± S.D. (n = 3). The pharmacokinetic parameters were determined as indicated under Materials and Methods. AUCR and C_maxR of CP dosed with PROB alone and with FSM compared with FSM group. Statistics were conducted by one-way ANOVA followed by Dunnett’s multiple comparison method.

Analyte	Pharmacokinetic parameters	Intravenous PROB dose
Analyte	Pharmacokinetic parameters	FSM alone	PROB alone	FSM with PROB
CPI	AUC_{0–24 h} (nM•h)	3.8 ± 1.1	2.9 ± 0.5	3.3 ± 1.1
	AUCR	1.0	0.78 ± 0.09	0.89 ± 0.15
	C_max (nM)	0.78 ± 0.26	0.56 ± 0.12	0.64 ± 0.26
	C_maxR	1.0	0.75 ± 0.13	0.84 ± 0.25
CPIII	AUC_0-7h (nM•h)	0.76 ± 0.22	1.05 ± 0.19	1.35 ± 0.50
	AUCR	1.0	1.5 ± 0.4	1.9 ± 0.7
	C_max (nM)	0.14 ± 0.04	0.25 ± 0.04^*	0.34 ± 0.11
	C_maxR	1.0	1.9 ± 0.5	2.5 ± 0.8

C_maxR, fold change in C_max.
↵^* P < 0.05 compared with the FSM group.