TABLE 2

SULT2A1 expression in cholestasis

CompoundsDisease modelsSpeciesExpression of Sult2a1MediatorsClinical outcomeReferences
YangoninEstrogen-induced cholestasisMouseFXRAttenuationGao et al., 2018; Dong et al., 2019
Auraptene17α-Ethinylestradiol–induced cholestasisMouseFXRAttenuationWang et al., 2019
TamoxifenCholestasisHuman/EnhancementBansal and Lau, 2019
Calculus bovis sativusEstrogen-induced cholestasisRatFXRAttenuationXiang et al., 2019
N-3 polyunsaturated fatty acids/Human cell line/Induce BA detoxificationCieślak et al., 2018
CorilaginANIT-induced cholestasisRatFXRAttenuationYang et al., 2018
DoxorubicinCholic acid-induced cholestasisMousep53AttenuationChen et al., 2017
GeniposideANIT-induced cholestasisRatFXRAttenuationWang et al., 2017
Alisol B 23-acetateEstrogen-induced cholestasisMouseFXRAttenuationMeng et al., 2015a
Alisol B 23-acetateANIT-induced cholestasisMouseFXRAttenuationMeng et al., 2015b
Oleanolic acidBile duct ligation–induced cholestasisRat/AttenuationChai et al., 2015a
Oleanolic acidLithocholic acid–induced cholestasisMouseERR2AttenuationChen et al., 2014
  • ANIT, alpha-naphthylisothiocyanate; BA, bile acid; ERR2, estrogen receptor–related receptor 2.