TABLE 2

Percent RMSE and half-life errors for each partition coefficient method and each drug

Percent RMSEHalf-Life Percent Error
Standardized TCReported TCStandardized TCReported TC
PTBerezRRSchmittPK-SimPTBerezRRSchmittPK-SimPTBerezRRSchmittPK-SimPTBerezRRSchmittPK-Sim
Metoprolol15115214214214515715714114214540.541.576.467.314142.543.430.2169175
Caffeine21.421.530.426.722.121.221.524.931.721.939.042.682.065.811840.644.713.415.0119
Voriconazole18.117.820.724.324.219.919.717.534.023.32252182734084562282231532610435
Alfentanil45.349.553.149.050.147.050.554.940.449.814335.710.941933115443.04.621360332
Nevirapine26.525.125.240.242.329.326.731.962.741.645.463.477.366154467.484.6128111524
Midazolam50.650.650.650.650.650.650.650.550.650.624.847.157.712.115.842.843.671.33.3119.2
S-Thiopental5.024.825.355.115.494.724.747.578.905.4429324615898.9229292253115255282
R-Thiopental4.255.547.874.133.395.436.3011.44.543.44261220139106255259226103284315
Nifedipine24.0111128044590.920.299.9128030.974.622.016.673.710130733.55.2673.921.8288
Digoxin17.918.320.411.413.217.718.124.737.913.017716312621931218817189.71150313
Artemether30.221.821.429.935.627.421.448.263.335.439.239.644.419.35.6956.848.934.041.31.15
Ofloxacin23.523.26.3824.023.423.323.110.912.021.959.359.019.359.859.259.159.037.040.257.5
Mean34.941.713971.142.235.341.614243.240.511499.394.818623112210471.1505239
  • TC, tissue composition.