TABLE 2

Pharmacokinetic data for the plasma, placenta, amniotic fluid, and fetus of fipronil (10 mg/kg, i.v.) in pregnant rats

Data are expressed as means ± S.D. (n = 6).

Pharmacokinetic ParameterPlasmaPlacentaAmniotic FluidFetusP Value
Fipronil
Tmax (h)0.25 ± 0.002.25 ± 1.602.00 ± 1.262.29 ± 2.520.125
Cmax (ng/ml)1060 ± 443.3a,b820.1 ± 282.6c,d182.7 ± 57.79286.4 ± 92.49<0.001*
AUClast (h ng/ml)2859 ± 1438a,b3411 ± 1097c,d787.4 ± 242.91085 ± 268.8<0.001*
AUC (h μg/ml)4468 ± 19336642 ± 3319c,d1253 ± 386.02204 ± 10060.002*
Fipronil sulfone
Tmax (h)4.17 ± 1.604.16 ± 1.694.83 ± 0.234.83 ± 1.170.619
Cmax (ng/ml)60.52 ± 32.24a,b52.80 ± 17.78c8.84 ± 3.9722.43 ± 5.79<0.001*
AUClast (h ng/ml)287.7 ± 162.2a,b215.5 ± 87.4554.72 ± 39.9684.06 ± 23.830.001*
  • a P < 0.05 compared with the plasma and amniotic fluid group.

  • b P < 0.05 compared with the plasma and fetus group.

  • c P < 0.05 compared with the placenta and amniotic fluid group.

  • d P < 0.05 compared with the placenta and fetus groups. *P < 0.05 compared among the plasma, placenta, amniotic fluid and fetus groups.