TABLE 4

Predicted rat hepatic clearance based on the extended clearance concept: CL_int,met × Kp_uu

Compound	Observed rat CL^a	CL_{int, met}		Temp Kp_uu,ss				Hom Kp_uu,ss				Kp_{uu, V0}
		CL_{int, met}		no BSA		with BSA		no BSA		w BSA		no BSA		w BSA
		Rat hepatocyte CL_int,met^{^b}	Pred rat CL	CL_int	Pred rat CL	CL_int	Pred rat CL	CL_int	Pred rat CL	CL_int	Pred rat CL	CL_int	Pred rat CL	CL_int	Pred rat CL
	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram	ml/min per kilogram
Rosuvastatin	56.7	77.0	5.23	1706	31.7	1541	30.6	1261	28.5	1901	32.7	5493	40.4	3794	38.3
Pravastatin	59.7	28.5^{^c}	14.51	373	38.6	161	31.7	83	24.5	88	25.2	257	35.9	1015	43.1
Valsartan	17.8	79.2	0.29	2107	5.4	844	2.3	471	1.3	9669	17.4	2962	7.2	1283	3.4
Pitavastatin	28.0	179	1.99	4848	18.7	3733	15.9	1372	7.5	2341	11.4	2904	13.4	2029	10.3
Fluvastatin	20.0	151	4.04	1557	15.5	5925	30.4	1241	13.3	4906	28.4	1306	13.8	3443	24.4
Cerivastatin	24.7	186	7.64	2719	29.1	1813	24.6	2523	28.3	4970	35.0	2385	27.7	1971	25.6
Nateglinide	58.1	169	3.23	2492	20.7	1135	12.4	525	6.7	1228	13.2	1209	13.0	519	6.7
Atorvastatin	35.0	353	14.04	5900	37.9	6275	38.4	2639	31.1	5089	36.9	7143	39.2	5836	37.9
Bosentan	23.0	153	1.98	1280	9.1	905	6.9	1018	7.6	1079	8.0	1466	10.2	2027	13.0
Glyburide	6.8	212	0.70	2375	4.3	6017	9.5	798	1.5	5911	9.4	6846	10.6	33,154	27.2
Asunaprevir	38.4	141	5.24	2280	18.1	4910	26.8	429	5.0	688	7.5	961	9.8	2357	18.4
Telmisartan	14.6	90.6	1.20	437	2.5	840	4.6	149	0.9	1378	7.1	ND	ND	7168	22.5

ND, not detected.
↵^a Refer to Table 2.
↵^b CL_{int, met} (milligrams per minute per kilogram) values was calculated based on the CL_{int, met} (microliters per minute per 10⁶cells) list in Table 1 using scaling factor of 108 × 10⁶ cells/g liver and 36 g liver/kg body weight.
↵^c Determined in rat liver S9 at unit of milliliters per minute per gram liver (Watanabe et al., 2009), converted to milliliters per minute per kilogram using scaling factor of 36 g liver/kg body weight.