PK Parameter | Blood Radioactivity | Plasma Radioactivity | Plasma Capmatinib |
---|---|---|---|

T_{max} [h] (median; range) | 2; 1 to 2 | 2; 1 to 2 | 2; 1 to 2 |

C_{max} [ng/ml]^{b} | 7300 (2880) | 7850 (3840) | 3670 (1710) |

T_{last} [h] (range) | 24–48 | 24–48 | 24–72 |

AUC_{last} [ng·h/ml]^{c}^{,}^{d} | 47,400 (13,700) | 43,800 (16,400) | 14,300 (5330) |

t_{1/2} [h] | 8.5 (4.8) | 10.6 (4.0) | 7.8 (3.1) |

AUC_{inf}^{e} [ng·h/ml]^{c}^{,}^{d} [% of^{14}C-AUC_{inf} plasma] | 49,700 (13,400) | 45,500 (15,900) | 14,400 (5310) |

114.3 (17.6) | – | 31.5 (2.9) | |

AUC%Extrap [% of AUC_{inf}] | 5.3 (3.9) | 5.0 (4.5) | 0.5 (0.6) |

Vz/F [l] | – | – | 624 (511) |

CL/F [l/h] | – | – | 51.7 (34.4) |

NA, not applicable; PK, pharmacokinetic; T

_{last}, time point corresponding to the last measurable concentration;*t*_{1/2}, half-life; –, not calculable/not meaningful.↵

^{a}Mean values are arithmetic means of individual values.↵

^{b}For radioactivity: [ng-eqper ml].↵

^{c}For radioactivity: [ng-eq·h per ml].↵

^{d}AUC_{last}were calculated using the linear trapezoidal rule. The typical time interval was 8–24 h for blood radioactivity and 12–48 h for plasma radioactivity and plasma capmatinib.↵

^{e}AUC_{inf}= AUC_{last}+ AUC_{t-inf}; AUC_{t-inf}= C_{last}**t*_{1/2}/ln2. Eq, equivalent; Extrap, extrapolated; AUC_{t-inf}; AUC from t_{last}to infinity.