TABLE 3

CBD inactivation kinetics of select CYPs in HLMs

Data represent means ± S.D. of four independent experiments.

EnzymeKI (μM)KI,u (μM)kinact (min−1)kinact/KI,u (min−1 μM−1)
CYP1A20.95 ± 0.420.11 ± 0.050.07 ± 0.010.70 ± 0.34
CYP2C193.33 ± 2.010.40 ± 0.240.04 ± 0.010.11 ± 0.06
CYP3A4.83 ± 2.100.58 ± 0.250.08 ± 0.020.14 ± 0.04