TABLE 3

Transcellular transport of DHC across MDCK-mock and MDCK-MDR1 cell monolayers

The data are shown as means ± S.D., n = 3. Unpaired Student’s t test was used to compare the differences between two groups.

PappMDCK-mock (×10−6 cm/s)MDCK-MDR1 (×10−6 cm/s)
AP-BLBL-APERAP-BLBL-APER
DHC2.93 ± 0.713.27 ± 0.191.123.46 ± 0.665.92 ± 0.321.71a
DHC + verapamil3.18 ± 0.683.40 ± 0.251.072.95 ± 0.272.53 ± 0.230.86b
Rhodamine 1231.99 ± 0.111.83 ± 0.230.921.06 ± 0.542.50 ± 0.032.36a
  • a P < 0.01 vs. ER of DHC in MDCK.

  • b P < 0.01 vs. ER of DHC in MDCK-MDR1.