TABLE 2

In vitro TDI parameter estimates for CA using numerical and replot methods

ParametersNumerical Method ModelsReplot Method
EII-MIC-M-IL Model 1a,bEII-MIC-M-IL Model 2aPI-M-IL
AICc−528.56−527.17−536.42
R20.99870.99870.9988
kinact (min−1)c0.003 ± 0.0010.023 ± 0.0120.100 ± 0.0100.025 ± 0.001
KI,u (μM)cKI,u1 = 60.69 ± 18.47KI,u1 = 60.00 ± 18.0637.44 ± 4.1515.24 ± 3.22
KI,u2 = 101.00 ± 90.29KI,u2 = 94.36 ± 81.09
  • a Two binding model.

  • b k8 fixed at 0.005 min−1.

  • c Estimated value ± S.E.