In vitro TDI parameter estimates for CA using numerical and replot methods
Parameters | Numerical Method Models | Replot Method | ||
---|---|---|---|---|
EII-MIC-M-IL Model 1a,b | EII-MIC-M-IL Model 2a | PI-M-IL | ||
AICc | −528.56 | −527.17 | −536.42 | — |
R2 | 0.9987 | 0.9987 | 0.9988 | — |
kinact (min−1)c | 0.003 ± 0.001 | 0.023 ± 0.012 | 0.100 ± 0.010 | 0.025 ± 0.001 |
KI,u (μM)c | KI,u1 = 60.69 ± 18.47 | KI,u1 = 60.00 ± 18.06 | 37.44 ± 4.15 | 15.24 ± 3.22 |
KI,u2 = 101.00 ± 90.29 | KI,u2 = 94.36 ± 81.09 |