TABLE 2

In vitro TDI parameter estimates for CA using numerical and replot methods

Parameters	Numerical Method Models			Replot Method
Parameters	EII-MIC-M-IL Model 1^{^a}^,^{^b}	EII-MIC-M-IL Model 2^{^a}	PI-M-IL	Replot Method
AICc	−528.56	−527.17	−536.42	—
R²	0.9987	0.9987	0.9988	—
k_inact (min⁻¹)^{^c}	0.003 ± 0.001	0.023 ± 0.012	0.100 ± 0.010	0.025 ± 0.001
K_I,u (μM)^{^c}	K_I,u1 = 60.69 ± 18.47	K_I,u1 = 60.00 ± 18.06	37.44 ± 4.15	15.24 ± 3.22
K_I,u (μM)^{^c}	K_I,u2 = 101.00 ± 90.29	K_I,u2 = 94.36 ± 81.09	37.44 ± 4.15	15.24 ± 3.22

↵^a Two binding model.
↵^b k₈ fixed at 0.005 min⁻¹.
↵^c Estimated value ± S.E.