Inhibitors | IC50 value | |||
---|---|---|---|---|
ODV | NDV | NODV | ||
RLM | ZJP (μg/ml) | 129.9 ± 2.6 | >575 | 42.8 ± 8.0 |
Berberine (μM) | 64.5 ± 11.5 | >1000 | 59.5 ± 18.6 | |
Coptisine (μM) | 27.0 ± 6.2 | >200 | 16.9 ± 0.1 | |
HLM | ZJP (μg/ml) | 30.5 ± 5.5 | >288 | 11.5 ± 10.2 |
Berberine (μM) | 30.5 ± 9.6 | >500 | >500 | |
Coptisine (μM) | 2.3 ± 1.3 | >100 | >100 | |
rhCYP2D6*1/*1 | ZJP (μg/ml) | 15.4 ± 4.5 | N/A | N/A |
Berberine (μM) | 2.5 ± 0.9 | |||
Coptisine (μM) | 0.7 ± 0.2 | |||
rhCYP2D6*10/*10 | ZJP (μg/ml) | 2.3 ± 1.0 | N/A | N/A |
Berberine (μM) | 1.5 ± 0.2 | |||
Coptisine (μM) | 2.2 ± 0.2 |
N/A, not applicable.