TABLE 2

Mean unbound concentrations of DHC in mouse plasma and heart after the oral administration of C. yanhusuo extract or DHC

The unbound concentrations of DHC in mouse plasma and heart was showed after the oral administration of C. yanhusuo extract (1.75 g·kg−1) containing DHC (25 mg·kg−1) or only DHC (25 mg·kg−1). The unbound concentrations of DHC in the heart were significantly higher than the concentrations in the plasma. The data are shown as means ± S.D., n = 8. The Kp,uu was described as the ratio of unbound tissue/unbound plasma concentration.

C. Yanhusuo ExtractDHC
Time (min)Plasma (ng/ml)Heart (ng/g)Heart/PlasmaPlasma (ng/ml)Heart (ng/g)Heart/Plasma
150.8256 ± 1.2497.9 ± 6396034.534 ± 3.8104.1 ± 9323
300.8872 ± 0.85101.1 ± 941140.1941 ± 0.1228.42 ± 2.9146
600.4612 ± 0.5933.16 ± 22720.9147 ± 1.234.26 ± 5.637