Parameter | Unit | WT | KO |
---|---|---|---|
Cmax | ng/ml | 108.0 ± 28.6 | 3.3 ± 1.6*** |
Tmax | min | 195.0 ± 62.1 | 255.0 ± 100.1 |
AUC0-t | ng·h/ml | 655.7 ± 243.7 | 25.3 ± 11.0*** |
AUC0-∞ | ng·h/ml | 750.5 ± 235.9 | 27.3 ± 12.6*** |
t1/2 | min | 162.1 ± 69.0 | 300.8 ± 124.6* |
MRT0-t | min | 293.6 ± 100.3 | 373.0 ± 72.2 |
MRT0-∞ | min | 328.0 ± 109.2 | 433.4 ± 119.1 |
AUC0−t, AUC at last time point measured; AUC0−∞, AUC extrapolated to infinity; MRT, mean residence time; Tmax, time to reach the peak plasma drug concentration.
↵* P < 0.05; ***P < 0.001 vs. WT mice.