TABLE 1

The pharmacokinetics parameters of COG in Mrp3 WT and KO mice after oral administration of 200 mg/kg of CUR

Data are presented as means ± S.D. (n = 8 each). Unpaired Student’s t test.

ParameterUnitWTKO
Cmaxng/ml108.0 ± 28.63.3 ± 1.6***
Tmaxmin195.0 ± 62.1255.0 ± 100.1
AUC0-tng·h/ml655.7 ± 243.725.3 ± 11.0***
AUC0-∞ng·h/ml750.5 ± 235.927.3 ± 12.6***
t1/2min162.1 ± 69.0300.8 ± 124.6*
MRT0-tmin293.6 ± 100.3373.0 ± 72.2
MRT0-∞min328.0 ± 109.2433.4 ± 119.1
  • AUC0−t, AUC at last time point measured; AUC0−∞, AUC extrapolated to infinity; MRT, mean residence time; Tmax, time to reach the peak plasma drug concentration.

  • * P < 0.05; ***P < 0.001 vs. WT mice.